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Approximately 80% of TTP is activated by deficient exercise of ADAMTS13. ADAMTS13 deficiency may be constitutive, as a result of biallelic ADAMTS13 pathogenic variants; or acquired, because of an inhibitory antibody. Analysis of ADAMTS13 activity is executed using tests according to the aptitude of your protease to cleave typical VWF multimers in v… Read More

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